Research topics

The main research topics of our group are:

• Identification of genetic factors predisposing to psychiatric disorders, mainly schizophrenia and substance use disorders

• Estimation of individual polygenic risk scores to develop psychiatric disorders due to common variants along the genome

• Association of polygenic risk scores with clinical features, such as symptoms severity and comorbidity

• Gene-set enrichment analysis to identify functionally related gene-sets involved in susceptibility to psychiatric disorders

• Identification of rare genetic variants of high impact to develop psychiatric disorders

• Interaction/correlation between genetic and environmental factors in susceptibility to psychiatric disorders

• Shared genetic susceptibility between different psychiatric disorders and its involvement in comorbidity, mainly between substance use disorders and other psychiatric disorder (i.e. dual diagnosis)

• Implications of shared genetic susceptibility between different psychiatric disorders for the hierarchical taxonomy of psychopatology